Why You Need to Pause Your GLP-1 Medication Before Surgery or Anesthesia
- Amira I. Quarles – AIQU
- Nov 4, 2024
- 4 min read
At Tried and True Weightloss, we are dedicated to supporting your health journey every step of the way. Whether it’s your day-to-day wellness or preparing for a surgery or medical procedure, we’ve got your back. If you're using GLP-1 medications like Semaglutide (Wegovy, Ozempic) or Tirzepatide (Mounjaro) as part of your weight loss plan, you may need to pause these medications before any procedure involving anesthesia.
Learn more about how GLP-1 medications support weight loss by visiting our Services page to learn more about GLP1 weight loss options and clinic offered complementary therapies.
Why Do You Need to Hold GLP-1 Medications Before a Procedure?
GLP-1 medications are a crucial part of your weight loss success. They help manage hunger and regulate blood sugar, making it easier for you to stay on track with your goals. However, they also slow down how quickly your stomach empties, which can pose a risk during surgery or when you’re under anesthesia.
Why does this matter? Anesthesia relaxes your muscles, including those that keep your stomach contents in place. If your stomach hasn’t fully emptied because of your medication, there’s a risk that food or liquids can enter your lungs—a serious complication called aspiration, which can lead to infections like pneumonia.
By holding your GLP-1 medication before a procedure, you give your body time to process any remaining food or liquid in your stomach, which reduces the risk of complications and ensures a safer experience under anesthesia.

For more information about the safety of anesthesia and medication, check out this anesthesia safety guide from the American Society of Anesthesiologists.
How Long Before Surgery Should You Pause GLP-1 Medications?
The timeline for pausing GLP-1 medications will vary based on what you’re taking and the type of procedure you’re having. Typically, for medications like Semaglutide or Tirzepatide, it’s recommended to stop them about one week before your surgery. However, it’s critical to follow the specific instructions from your healthcare team. We’ll work closely with your surgeon or doctor to make sure everything is aligned for a safe procedure and smooth recovery.
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What to Expect When You Pause Your GLP-1 Medication
Pausing your medication can feel a bit unsettling, especially if you’ve come to rely on it to help control your appetite. You might notice that familiar cravings return, or that you feel hungrier than usual. Don’t worry—this is completely normal and temporary.
The key is to stay focused on the healthy habits you’ve built. Stick with your routines, watch your portion sizes, and remind yourself that this is just a short break in the grand scheme of your weight loss journey. At Tried and True Weightloss, we’re here to help! If you need advice or tips to manage your appetite while your medication is paused, don’t hesitate to reach out.
Explore our Essential Weight Management Tips for Long-Term Success for more ways to stay on track during your GLP-1 pause.
Getting Back on Track After Surgery
After your surgery, your healthcare team will let you know when it’s safe to restart your GLP-1 medication. The timing will depend on how well your body is healing, but most patients can resume their medications within a few days. Once you’re back on track, we’ll help you ease into your routine again and continue making progress toward your weight loss goals.
Looking to get back on track quickly after surgery? Schedule a follow-up with us today to discuss your post-procedure plan. Book your appointment here.
Additional Educational Resources
We believe in giving you all the tools you need to make informed decisions about your health. Below are some additional resources that can help you better understand the relationship between GLP-1 medications, surgery, and anesthesia:
Preoperative Fasting and the Use of Medications in the Perioperative Period (National Library of Medicine)
The Importance of Stomach Emptying and Anesthesia (National Institutes of Health)
Managing Your Weight Loss Plan During Medical Procedures (CDC)
At Tried and True Weightloss, we are committed to helping you navigate every step of your health journey. Pausing your GLP-1 medication before surgery may feel like a small hiccup, but it’s an important part of keeping you safe and ensuring a successful procedure. If you have any questions about pausing your medication or preparing for surgery, reach out to us. We’re here to make sure you feel confident, informed, and supported—every step of the way.
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To learn more about GLP1 medication options please read our article titles "Introduction to GLP1 Weightloss Medications" as well as visiting the offered GLP1 services- Semaglutide, Tirzepatide and our ever changing and adapting list of Complementary Services -adaptive to our specific patient needs- to aid as weight loss and wellness boosters throughout each individualized journey.
Ready to Begin Your Journey? Let us guide you on the path to sustainable weight management. Visit Tried and True Weightloss or click the button below to Learn More About Us. Here’s to a balanced, vibrant, and healthier you!
Content Information by Amira I. Quarles, CRNP-MSN a practicing Nurse Practitioner, based in Pittsburgh and additionally licensed to treat and prescribe in South Dakota. Please view the following link if you are wanting to "Get to know more about Amira I. Quarles, CRNP." You can also learn more about Amira Q+U by visiting her Amira's linked-in page.
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